In the journey of assisted reproductive technology (ART), the pursuit of
successful pregnancy starts with precise monitoring and effective intervention.
Among the numerous biological indicators and therapeutic agents, Human chorionic
gonadotropin (hCG) plays an irreplaceable dual role—as a reliable early
pregnancy marker and a critical "trigger" for ovulation. This glycoprotein
hormone secreted by placental trophoblast cells not only provides the earliest
signal of conception but also lays the foundation for optimizing ovulation
timing in ART cycles, becoming a core focus for both clinicians and infertile
couples.
One of the most remarkable values of Human chorionic gonadotropin lies in
its high sensitivity and specificity in early pregnancy diagnosis. Unlike urine
testing, blood hCG detection can capture extremely low levels of the hormone as
early as 8-10 days after conception, serving as the "gold standard" for early
pregnancy confirmation. Recent clinical studies have further refined the
predictive value of hCG at different time points after embryo transfer. For
example, a study on frozen blastocyst transfer found that a blood hCG level ≥4.0
IU/L on the 5th day after transfer indicates a high probability of pregnancy,
with a sensitivity of 93.4% and a specificity of 92.7% . Such precise early
prediction not only helps reduce the anxiety of couples waiting for results but
also enables clinicians to timely formulate personalized luteal support plans,
maximizing the potential of successful pregnancy.
Beyond its diagnostic role, Human chorionic gonadotropin is also a crucial
trigger agent in controlled ovarian hyperstimulation (COH) for ART. When
dominant follicles reach a diameter of 18-20mm and estrogen levels meet the
required threshold, injecting hCG can simulate the physiological LH peak,
promoting the final maturation and ovulation of oocytes. This "trigger" effect
is essential for synchronizing ovulation with embryo transfer timing, a key
factor affecting fertilization success. Compared with other trigger methods, hCG
trigger has been widely used in clinical practice due to its stable efficacy and
clear action mechanism, especially suitable for patients with normal ovarian
reserve .
The clinical significance of Human chorionic gonadotropin is further
reflected in its role in monitoring embryonic development. In normal pregnancy,
hCG levels double approximately every 1.7-2.0 days in the early stage and peak
at 8-10 weeks of gestation. Abnormal changes in hCG levels, such as slow growth
or abnormal elevation, can help clinicians identify potential risks such as
ectopic pregnancy, molar pregnancy, or early abortion . For instance, a study
involving 772 single blastocyst transfer cycles showed that a hCG level ≥113.28
mIU/mL on the 10th day after transfer corresponds to a 98.6% probability of
successful pregnancy, and this threshold varies moderately with age, providing a
personalized reference for clinical monitoring .
At Kangyuan, we recognize the pivotal role of Human chorionic gonadotropin
in the ART process and are committed to providing high-quality pharmaceutical
products and professional technical support for global reproductive healthcare.
Our hCG-related products adhere to strict international quality control
standards, ensuring stability and reliability to support accurate clinical
diagnosis and effective treatment. If you are undergoing ART treatment, seeking
reliable early pregnancy monitoring solutions, or need professional advice on
ovulation induction triggers, please do not hesitate to contact our team. We
will work closely with you to interpret the signals of hCG and help you move
smoothly towards the dream of parenthood.