With the rapid development of modern society, the incidence of infertility
is increasing year by year. At present, about 15% of couples of childbearing age
are facing fertility problems, and there is an increasing trend.
Oligospermozoospermia is the most common cause of male infertility. The
pathogenesis of severe oligo asthenozoospermia has not been fully clarified, and
drugs with clear curative effects are still rare, which is one of the most
difficult problems for clinicians. The necessity of follicle-stimulating hormone
(FSH) in regulating and maintaining human spermatogenesis is well known, and FSH
plays an important role in maintaining Sertoli cell function as well as in
spermatogenesis.
Urofollitropin (urine Follicle Stimulating Hormone, u-FSH) is a composition
whose main component is Follicle Stimulating Hormone (FSH). The FSH content in
high-purity Urofollitropin can reach more than 95%, and it hardly contains
Luteotropic Hormone (LH). FSH is a glycoprotein hormone with a molecular weight
of about 30KD. FSH can promote the proliferation of granulosa cells, stimulate
steroid production, regulate the development and maturation of gametocytes, and
is one of the main hormones in the hypothalamus-pituitary-gonad axis.
FSH has the functions of regulating the menstrual cycle, ovulation, and
regulating male testicular function in humans. It is commonly used clinically to
treat female infertility, insufficient secretion of male gonadotropin, and
deficient seminiferous tubules. In the human pituitary gland and in the urine of
menopausal and postmenopausal women, the content of the two is higher, so it is
also the main source of extracting FSH. The raw material for the production of
u-FSH is human menopausal gonadotropin (Human Menopausal Gonadotropin, HMG),
which mainly includes follicle-stimulating hormone and luteinizing hormone
(Luteotropic Hormone, LH). The ratio of FSH to LH titer is about 1:1. To prepare
high-purity Urofollitropin, LH and other urinary proteins in HMG need to be
removed, and FSH, which is a single active component of high purity, should be
retained.