Kangyuan is a private pharmaceutical enterprise group with 32 years of
entrepreneurial history, integrating scientific research, production and sales,
from initial raw materials to high-quality raw materials to preparations, and a
complete industrial chain from China to the world.
There are many types of products. Today we introduce: Urofollitropin
Organic solvent is ethanol or acetone and its concrete steps are:
(1) adjust ffl value: adjust the pH value of raw material to 8.0～9.0 with
20 F. sodium hydroxide; (2) filter, ultrafiltration concentrate: after adjusting
pH value, add 1% diatomaceous earth in urine Filtrate, pour the filtrate into an
ultrafiltration tank, and concentrate by ultrafiltration through a 10,000
molecular weight ultrafiltration membrane;
(3) Organic solvent precipitation: under stirring, first add 10% ammonium
acetate and organic solvent to the concentrated solution to make the
concentration of the organic solvent reach 70-75%, filter, collect the clear
liquid, and then add the organic solvent to the solution, Make the concentration
of the organic solvent reach 80-85%, stir evenly and then let it settle for 3-5
hours, collect the precipitate by filtration, wash with the organic solvent 2-3
times, dehydrate and dry to obtain the crude follicle-stimulating hormone.
Above-mentioned organic solvent is ethanol or acetone.
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