Urokinase, as a thrombolytic drug for patients with thrombosis, currently
has no suitable alternatives, and there is a serious shortage of Urokinase in
the pharmaceutical market, so it has attracted the attention of the media and
the public. In the current Urokinase extraction process, about one ton of urine
can extract 120-150g of Urokinase, the technical difficulty is not high, there
are mainly three extraction methods as follows.
1. Precipitation method: use a precipitating agent, put the agent into the
urine, and finally precipitate the crude Urokinase.
2. Soaking method: First, stir the urine at a high speed, add ammonium
sulfate after stirring the foam, and get the crude Urokinase Precipitant method:
The precipitation method is to add a precipitant to the urine to precipitate
3. Adsorbent method: The adsorption method is to add "adsorbent" to the
urine to absorb Urokinase. At present, the adsorption method is the most widely
used in the Urokinase extraction process. Adsorbents include resin adsorption
and diatomite adsorption.
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