As a thrombolytic drug for thrombus patients, urokinase is currently not
available as an alternative drug, and there is a serious shortage of urokinase
in the pharmaceutical market, so it has attracted the attention of the media and
the public. The current urokinase extraction process, about a ton of urine can
extract 120-150g of urokinase, urokinase technology is not very difficult, there
are mainly the following three extraction methods
First, precipitation method: the use of precipitating agent, the agent into
the urine, and finally precipitate urokinase crude
Two, soaking method: first of all, high-speed stirring urine, stirring the
foam after adding ammonium sulfate, urokinase crude precipitating agent method:
precipitation method is to add precipitating agent in urine, so that urokinase
precipitation out of the obtained.
Three. Adsorbent method: Adsorption method is to add "adsorbent" in urine to
adsorb urokinase. At present, adsorption method is the most widely used in
urokinase extraction process. Adsorbent includes resin adsorption and
diatomaceous earth adsorption two processes
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