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Human chorionic gonadotropin API Supplier: Notes

  Human chorionic gonadotropin Pharmacodynamics

  Chorionic gonadotropin (HCG) is a gonadotropin secreted by placental trophoblast cells and is present in the urine and blood of pregnant women. The secretion is very fast in the first trimester, and the secretion peaks at 8-10 weeks of pregnancy. HCG can be dissociated into two subunits, α and β, and each subunit contains a side chain composed of several sugar molecules. The α subunit has a molecular weight of 14500-18000 and a total of 89-92 amino acids. Its sequence is very similar to the glycoprotein hormones secreted by the pituitary gland, such as follicle stimulating hormone (FSH) and luteinizing hormone (LH). The molecular weight of the β subunit is 22200-39000, with 145-147 amino acids. The first 110 or so amino acids are basically the same as LH, but the arrangement of the last few amino acids is different, and there are 28-32 amino acid fragments that are unique to HCG. Antigenic and immunologically active. 

Human chorionic gonadotropin API Supplier: Notes

     The biological activity of HCG is relatively complex. When it is decomposed into two independent subunits, α and β, it has no biological activity, and only the two subunits are combined to have activity. Since the α subunit of HCG and LH are the same, and the β subunit is also very similar, the biological activities are similar. At present, there is no LH preparation, and HCG is used clinically to replace LH, which can be used as a substitute for endogenous LH in the luteal phase.

  Chorionic gonadotropin is very similar to LH secreted by the pituitary gland, while FSH has little effect and has strong antiestrogen and weak estrogenic activity. This drug can stimulate the gonadal activity, maintain and promote the luteal function in women, make the corpus luteum synthesize progesterone, and combined with the urinary gonadotropin with FSH component can promote the formation and maturation of follicles, and can simulate the physiological LH peak and trigger the ovulation. For men, this drug has the effect of promoting interstitial cytokines, which can promote the function of seminiferous tubules, especially the activity of testicular interstitial cells, so that they can produce androgens, and promote the development and maturation of sexual organs and male secondary sexual characteristics. , promote testicular descent, and promote sperm production.

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