Urokinase can directly act on the endogenous fibrinolytic system and can
catalyze the cleavage of plasminogen into plasmin. Plasmin can not only degrade
fibrin clots, but also degrade fibrinogen and coagulation factor five in the
blood circulation. And coagulation factor eight, so as to play a thrombolytic
effect. Urokinase has a fast onset and good effect on newly formed thrombus.
Urokinase can also increase the activity of vascular ADP enzyme, inhibit
ADP-induced platelet aggregation and prevent thrombosis. After intravenous
infusion of urokinase, the plasmin activity in the patient's body was
significantly increased, and after a few hours of drug withdrawal, the plasmin
activity returned to the original level, but the plasma, fibrin, and fibrinogen
levels decreased, and their degradation The increase of the product can last for
12 to 24 hours, and the thrombolytic effect of urokinase is obviously related to
the dose of the drug and the time window of administration.
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