Urokinase is a serine protease produced by human renal tubular epithelial
cells and is a mixture of high molecular weight urokinase (HUK, 54000) and low
molecular weight urokinase (LUK, 33000). It is a highly specific and selective
proteolytic enzyme.
Plasminogen is the only natural protein substrate. This
product acts on the arginine-valine bond on plasminogen to convert plasminogen
into active plasmin. The activity of this product on synthetic substrates is
similar to that of trypsin and plasmin, and it also has the activity of
esterase. Isoelectric point pl 8.4 ~ 8.7. No antigenicity, does not make
antibodies in the body. In vivo tl/2 was (14±6) min. The freeze-dried state can
be stable for several years, and the diluted solution is unstable and must be
used fresh. This product is white non-crystalline powder, easily soluble in
water.
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