Urokinase Instructions are more and more widely used now, so many customers
do not know about its pharmacology and toxicology. The following Xiaobian from
Kangyuan will give you a detailed introduction, hoping to help you.
Urokinase acts directly on the endogenous fibrinolytic system and can
catalyze the cleavage of plasminogen into plasmin, which not only degrades
fibrin clots, but also degrades fibrinogen, coagulation factor V and coagulation
factors in the blood circulation VIII, etc., thereby exerting a thrombolytic
effect. This product has fast onset and good effect on newly formed thrombus.
This product can also improve vascular ADP enzyme activity, inhibit ADP-induced
platelet aggregation, and prevent thrombosis. After intravenous infusion of this
product, the plasmin activity in the patient's body was significantly increased;
after a few hours of drug withdrawal, the plasmin activity returned to its
original level. However, a decrease in plasma fibrin or fibrinogen levels, as
well as an increase in their degradation products, can persist for 12-24 hours.
This product shows that the thrombolytic effect is significantly correlated with
the drug dose and the time window of administration.
The toxicity of Urokinase is very low, and the median lethal dose of
intravenous injection in mice is more than 1 million units/kg body weight. No
obvious antigenicity, teratogenicity, carcinogenicity and mutagenicity. Rare
reports of allergic reactions in clinical applications. However, since this
product increases plasmin activity and reduces circulating unconjugated
plasminogen and fibrin-bound plasminogen, there may be a serious risk of
bleeding.
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