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of Human Menopausal Gonadotropin.
Urinary gonadotropin is extracted from the urine of menopausal women, which
contains two hormones, FSH and LH, in a ratio of about 1:1. It mainly has the
function of follicle-stimulating hormone (FSH) and the biological activity of
luteinizing hormone (LH). Most patients with ovulation disorders have FSH and LH
lower than normal, and there is a close correlation between FSH and LH. When the
ratio is too low or the ratio is abnormal, it will cause abnormal follicle
development and ovulation disorders. FSH has the functions of regulating the
dominant follicle, recruiting, developing and atresia of the non-dominant
follicle; LH plays an important role in the follicle development, egg maturation
and ovulation process. The use of LH-containing gonadotropin to induce ovulation
can reduce the formation of small follicles. Atresia, stimulate the development
and function of large follicles, improve the properties of cervical mucus and
the shape of the endometrium, and improve the pregnancy rate. For women, it can
promote the development and maturation of follicles, promote the secretion of
estrogen from the follicles, and make the endometrium hyperplasia. When the
pituitary gland is insufficiency or the response of the follicles to
gonadotropins changes, it can be used in combination with chorionic gonadotropin
to promote ovulation. ; For males, it can promote the development of the
seminiferous tubules in the testis, and promote the division of spermatogenic
cells and sperm maturation. Long-term application does not produce antibodies
and no allergic reactions. It is mainly used in combination with chorionic
gonadotropin (HCG) or clomiphene to treat anovulatory infertility. It is
suitable for patients with hypothalamic and pituitary dysfunction or
hypogonadotropic hypogonadism to stimulate follicle maturation. In medical
assisted reproductive technology (ART), it is used to stimulate the maturation
of multiple follicles. Men are used for azoospermic or oligospermic patients
with primary or secondary hypogonadotropic hypogonadism to stimulate sperm
production.
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