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Urokinase Instructions to you.
【Urokinase function and indications】This product directly acts on the
endogenous fibrinolytic system, and can catalyze the cleavage of plasminogen
into plasmin, which can not only degrade fibrin clots, but also degrade
fibrinogen in the blood circulation, Coagulation factor V and coagulation factor
VIII, etc., so as to play a thrombolytic effect. This product has fast onset and
good effect on newly formed thrombus. This product can also improve vascular ADP
enzyme activity, inhibit ADP-induced platelet aggregation, and prevent
thrombosis. After intravenous infusion of this product, the plasmin activity in
the patient's body was significantly increased; after a few hours of drug
withdrawal, the plasmin activity returned to its original level. However, a
decrease in plasma fibrin or fibrinogen levels, as well as an increase in their
degradation products, can persist for 12-24 hours.
This product shows that the
thrombolytic effect is significantly correlated with the drug dose and the time
window of administration. The toxicity of this product is very low, and the
median lethal dose of intravenous injection in mice is more than 1 million
international units/kg body weight. No obvious antigenicity, teratogenicity,
carcinogenicity and mutagenicity. Rare reports of allergic reactions in clinical
applications. However, since this product increases plasmin activity and reduces
circulating unconjugated plasminogen and fibrin-bound plasminogen, there may be
a serious risk of bleeding.
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