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Urokinase Instructions: Function Indications

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  【Urokinase function and indications】This product directly acts on the endogenous fibrinolytic system, and can catalyze the cleavage of plasminogen into plasmin, which can not only degrade fibrin clots, but also degrade fibrinogen in the blood circulation, Coagulation factor V and coagulation factor VIII, etc., so as to play a thrombolytic effect. This product has fast onset and good effect on newly formed thrombus. This product can also improve vascular ADP enzyme activity, inhibit ADP-induced platelet aggregation, and prevent thrombosis. After intravenous infusion of this product, the plasmin activity in the patient's body was significantly increased; after a few hours of drug withdrawal, the plasmin activity returned to its original level. However, a decrease in plasma fibrin or fibrinogen levels, as well as an increase in their degradation products, can persist for 12-24 hours. 

Urokinase Instructions: Function Indications

      This product shows that the thrombolytic effect is significantly correlated with the drug dose and the time window of administration. The toxicity of this product is very low, and the median lethal dose of intravenous injection in mice is more than 1 million international units/kg body weight. No obvious antigenicity, teratogenicity, carcinogenicity and mutagenicity. Rare reports of allergic reactions in clinical applications. However, since this product increases plasmin activity and reduces circulating unconjugated plasminogen and fibrin-bound plasminogen, there may be a serious risk of bleeding.

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