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Urokinase Instructions to you.
[Pharmacological action of Urokinase] This product directly acts on the
endogenous fibrinolysis system and can catalyze the cleavage of plasminogen into
plasmin, which can not only degrade fibrin clots, but also degrade fibrinogen
and coagulation in the blood circulation. Factor V and coagulation factor VIII,
etc., so as to play a thrombolytic effect. The product has fast onset and good
effect on newly formed thrombus. The product can also improve vascular ADP
enzyme activity, inhibit ADP-induced platelet aggregation, and prevent
thrombosis. After intravenous infusion of this product, the activity of plasmin
in the patient's body was significantly increased; after a few hours of drug
withdrawal, the activity of plasmin returned to its original level, but the
level of plasma fibrin or fibrinogen decreased, and their degradation products
increased Can last 12-24 hours. The product shows that the thrombolytic effect
is significantly correlated with the drug dose and the time window of
administration. The toxicity of this product is very low, and the median lethal
dose of intravenous injection in mice is more than 1 million international
units/kg body weight. There is no obvious antigenicity, teratogenicity,
carcinogenicity and mutagenicity. Rarely, allergic reactions have been reported
in clinical applications; however, since this product increases plasmin activity
and reduces circulating unconjugated plasminogen and fibrin-bound plasminogen, a
serious bleeding risk may occur.
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