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Urokinase should be prepared with sodium chloride injection or 5% glucose
solution before use.
1.Initial dose of pulmonary embolism 4400 units/kg, prepared with sodium
chloride injection or 5% glucose solution, dropped within 10 minutes at a rate
of 90 ml/h; It was administered at a rate of 4400 units per hour for 2 hours or
12 hours continuously. In case of pulmonary embolism, it can also be injected
into the pulmonary artery after being prepared by 15000 units of sodium chloride
injection per kilogram of body weight. If necessary, the dose can be adjusted
according to the situation. Repeat once every 24 hours and use up to three
times.
2. For myocardial infarction, it is recommended that sodium chloride
injection be prepared and intravenously injected for 2 hours at a rate of 6000
units/min. 2500-10000 units of heparin should be given intravenously before
infusion. Alternatively, 2 to 3 million units of urokinase can be prepared for
intravenous drip, 45 minutes to 90 minutes.
3. Peripheral arterial thrombosis Blood clots were treated with urokinase
prepared by sodium chloride injection (2500 units/ml) at a rate of 4000
units/min through catheters. Clamp the catheter once every 2 hours; Adjust the
drip rate to 1000 units/min until the clot dissolves.
Prevention and treatment of thrombosis after heart valve replacement
Thrombosis is one of the most common complications after heart valve
replacement. Urokinase 4400 units/kg body weight can be used, and sodium
chloride injection is prepared in 10 to 15 minutes after dropping. It was then
maintained at 4400 units/kg/h by intravenous drip. Discontinue medication when
the valve functions normally. If the medication is still ineffective within 24
hours or serious bleeding tendency occurs, the medication should be
discontinued.
5. Empyema or pericardial pus is often treated with antibiotics and pus
drainage. The drainage tube is often blocked by clumps of fibrin. 10000 to
250000 units of urokinase prepared with sterile water for injection (5000
units/ml) can be injected into the thorax or pericardium. It can not only keep
the drainage tube unobstructed, but also prevent pleura or pericardium adhesion
or pericardium constriction.
6. Ophthalmic application to dissolve blood clots in the anterior chamber
caused by intraocular bleeding. Disintegrate the clot and facilitate surgical
removal. The usual dosage is 5000 units. Rinse the anterior chamber with 2 ml
sodium chloride injection.
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