Urokinase can directly act on the endogenous fibrinolytic system and
catalyze the lysis of plasminogen into fibrinolytic enzyme. Plasminolytic enzyme
can not only degrade fibrinogen clots, but also degrade fibrinogen, coagulation
factor 5 and coagulation factor 8 in blood circulation, so as to play the role
of thrombolysis.
What is the role of urokinase?
Secondly, urokinase has a fast and good effect on newly formed thrombosis.
Urokinase can also improve vascular ADP enzyme activity, inhibit ADP-induced
platelet aggregation and prevent thrombosis.
Urokinase in patients with intravenous drip, fibrinolytic enzyme activity
increased significantly in the body, to a few hours after stopping drug,
fibrinolytic enzyme activity to restore the original level, but plasma, fibrin
and fibrinogen level is reduced, and the increase of their degradation products
can last 12 to 24 hours, the thrombolytic effect of urokinase and drug dosage,
dosing time window has obvious relevance.