Urokinase is mainly a drug that dissolves thrombus. Urokinase acts directly
on the endogenous fibrinolytic system and catalyzes the lysis of plasminogen
into fibrinolytic enzyme, which can not only degrade fibrinogen clots, but also
degrade fibrinogen, coagulation factor Ⅴ and coagulation factor in blood
circulation, so as to play the role of thrombolysis. After intravenous infusion
of urokinase, the activity of plasminase in patients was significantly
increased. A few hours after drug withdrawal, plasminase activity returned to
its original level. It can treat venous thrombosis, thrombosis in acute
myocardial infarction.
Urokinase has side effects, and the common side effect is bleeding
symptoms, so when using urokinase, it is necessary to monitor the clotting time,
as well as to see if there are bleeding gums, black stool and other bleeding
symptoms.
The role and side effects of urokinase are introduced here, more details
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