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Urokinase should be prepared with sodium chloride injection or 5% glucose
solution before clinical use.
1.The initial dose of 4400 units/kg for pulmonary embolism was prepared
with sodium chloride injection or 5% glucose solution and dropped within 10
minutes at a rate of 90 ml/h; It was then administered at a rate of 4400 units
per hour, with continuous intravenous infusion for 2 hours or 12 hours. In case
of pulmonary embolism, sodium chloride injection of 15000 units per kg body
weight can also be prepared and injected into the pulmonary artery. If
necessary, adjust the dosage according to the situation. Repeat once every 24
hours, and use up to three times.
2. For myocardial infarction, it is suggested that sodium chloride
injection should be prepared and continuously injected into the coronary artery
at a rate of 6000 units/min for 2 hours. Before the infusion, 2500-10000 units
of heparin should be given intravenously. Urokinase 2 to 3 million units can
also be prepared after intravenous infusion, 45 minutes to 90 minutes after
dripping.
3. Peripheral arterial thrombosis: sodium chloride injection was used to
prepare urokinase (concentration: 2500 units/ml) and the blood clot was injected
at a rate of 4000 units/min via catheter. Clip the catheter once every 2 hours;
The infusion rate can be adjusted to 1000 units/min until the clot
dissolves.
4. Prevention and Treatment of Thrombosis After Heart Valve Replacement
Thrombosis is one of the most common complications after heart valve
replacement. Urokinase 4400 units/kg body weight, sodium chloride injection
preparation after 10 minutes to 15 minutes to drop. It was then maintained by
intravenous infusion of 4400 units/kg body weight/hour. When the valve function
is normal, the medication is stopped. If the drug is still ineffective for 24
hours or serious bleeding tendency should be stopped.
5. Pempyema or pericardium is usually treated with antibiotics and pus
drainage. The drainage tube is often blocked by the formation of a clot of
fibrin. At this time 10000 to 250000 units of urokinase prepared with sterile
water for injection (5000 units/ml) can be injected into the pleural or
pericardial cavity. It can not only keep the drainage tube patency, but also
prevent pleura or pericardium adhesion or the formation of pericardial
constriction.
6. Ophthalmological applications are used to dissolve anterior chamber
blood clots caused by intraocular bleeding. To disintegrate the clot and
facilitate surgical removal. Flush the anterior chamber with 2 ml sodium
chloride injection, usually 5000 units.
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