Industry Information

Gonadotropin use

  One, gonadotropin application

  Gonadotropin obtained from animal pituitary gland has been widely used in animal husbandry and aquaculture, but has no effect on human beings. HCG can be prepared from the urine of pregnant women, or the mixed preparation of LH and FSH extracted from the urine of menopausal women, referred to as human menopausal gonadotropin (HMG), which can be used to treat hyposexual dysfunction clinically.

Gonadotropin use

  two. Secretion mechanism

  The production and release of pituitary gonadotropin is directly regulated by hypothalamic luteinizing hormone releasing hormone (LH-RH). Sex hormones, the target gland products of LH and FSH, can in turn affect the secretion function of the pituitary or hypothalamus. Therefore, the secretion of LH-RH, LH, FSH and sex hormones is restricted mutually, and the ups and downs are quite rhythmical. The recurrent occurrence of a woman's menstrual cycle is the result of the ups and downs and rhythmic changes in the secretion of these tertiary hormones.

  Three, the structure

  Gonadophilic hormone (LH, FSH, HCG) and thyroid stimulating hormone (TSH) are composed of α and β peptide chains combined by non-covalent bonds, and contain glycogroups, which are partially bound to individual asparagine residues, serine residues or threonine residues on the peptide chains by covalent bonds. Two peptide chains can be separated and recombined. The α -peptide chains of LH, FSH, HCG and TSH have the same structure, while the β -peptide chains have their own characteristics, which determine the functional specificity of these hormones.