Industry Information

What does the item of attention of medication with urokinase have for injection?

  1. Before urokinase for injection, hematocrit, platelet count, thrombin time (TT), prothrombin time (PT), and activated partial thromboplastin time (APTT) should be measured in the patient. TT and APTT should be less than 2 times longer within the range.

  2. During medication, patients' reactions should be closely observed, such as pulse rate, body temperature, respiratory rate, blood pressure, bleeding tendency, etc., and recorded at least once every 4 hours.

What does the item of attention of medication with urokinase have for injection?

  3. During intravenous administration, puncture is required to be successful once to avoid local bleeding or hematoma.

  4. During the administration of arterial puncture, pressure should be applied to the puncture area for at least 30 minutes after the administration, and then pressurized and bandaged with sterile bandage and dressing to avoid bleeding.

  5. Urokinase for injection will increase the risk in the following situations, and should be used with caution after weighing the advantages and disadvantages:

  (1) Patients who delivered within the last 10 days, underwent tissue biopsy, venipuncture or major surgery, and patients with severe gastrointestinal bleeding.

  (2) Patients at high risk of left ventricular thrombosis, such as mitral stenosis with atrial fibrillation.

  (3) Patients with subacute bacterial endocarditis.

  (4) Patients with bleeding tendency or coagulation disorder secondary to liver and kidney diseases.

  (5) Pregnant women, cerebrovascular disease, and diabetic hemorrhagic retinopathy.

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