Urokinase can directly act on the endogenous fibrinolytic system and
catalyze the lysis of plasminogen into fibrinolytic enzyme, which can not only
degrade fibrinogen clots, but also degrade fibrinogen, coagulation factor Ⅴ and
coagulation factor in blood circulation, so as to play the role of
Adverse reactions should be noted when using urokinase:
1, when the dosage is large, a few patients may have bleeding phenomenon,
mild bleeding such as skin, mucous membrane, naked eye and microscope hematuria,
blood sputum or small amount of hemoptysis, hematemesis, etc., take appropriate
measures, the symptoms can be relieved. In case of serious bleeding, such as a
large number of haemoptysis or digestive tract hemorrhage, retroperitoneal
bleeding, intracranial and spinal cord, mediastinal or pericardium hemorrhage,
etc., should be suspended use, loss of blood to lose whole blood (it is better
to blood, do not use the generation of plasma), can get effective control,
consider using amino caproic acid in an emergency, aminomethylbenzoic acid
2, a few patients can appear allergic reaction: generally mild, such as
bronchospasm, rash and so on. Occasionally anaphylactic shock is seen.
3, fever: about 2 ~ 3% of patients can see different degrees of fever.
Acetaminophen can be used as an antipyretic. Do not use aspirin or other
antiplatelet effect of antipyretics.
4. Others: nausea, vomiting, loss of appetite, fatigue, and elevation of
ALT can also be seen. Can cause bleeding, a few have allergic reaction,
headache, nausea, vomiting, loss of appetite and so should be stopped
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