Industry Information

The Urokinase manufacturer describes the considerations for Urokinase

  Kangyuan is a professional Hormone API Manufacturer, which is your best choice. Let's introduce Urokinase manufacturer.

  Urokinase is an enzyme protein isolated from the urine of healthy people or obtained from human kidney tissue cultures. Urokinase can activate plasminogen to plasminogen in vivo, thus hydrolyzing fibrin to dissolve freshly formed thrombus. It is mainly used for thrombolytic therapy of thromboembolic diseases. What are the precautions for the use of urokinase?

  1. Urokinase can cause pinhole bleeding at the injection site, so puncture and other operations should not be performed during medication.

  2. Before use, bleeding time, partial thromboplastin production time, prothrombin time, thrombin time, platelet count, hemoglobin, blood cell volume, etc., should be detected to exclude bleeding constitution.

The Urokinase manufacturer describes the considerations for Urokinase

  3. Urokinase is easy to decompose and reduce the effect in acidic medicine solution, so the diluent used should be close to neutral. When diluted with glucose injection, choose a product with a pH of 4.5 or greater.

  4. Enough initial amount of urokinase must be given within a short time (15-30min) to neutralize urokinase antibodies in the body. However, if the initial dose is too large, the plasminogen library and coagulation factors Ⅰ, Pt and Bt in vivo will be depleted and the effect of thrombolysis will be affected.

  5. Urokinase is only for intravenous injection and intracardiac injection, and can not be intramuscular or local injection.

  6. Urokinase solution must be prepared fresh before use and used with it. Urokinase is dissolved in 5ml of sterilized water for injection (not dissolved in other solutions). The resulting solution is allowed to be light straw yellow (dark or insoluble should not be applied). When dissolving, the bottle should be rotated gently, and do not shake vigorously (because it can produce insoluble matter). The prepared liquid should be passed through 0.45μm terminal filter or small celluloid filter to remove insoluble particles, and then diluted for reserve according to the requirements of usage.

  Above is the relevant content summarized by Kang Yuan's editor. If you want to know more, please follow us. We will update you regularly about Human Chorionic Gonadotropin, Human Menopausal Gonadotropin supplier, Urofollitropin price, Urokinase manufacturer, Hormone API manufacturer.