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Points to note when taking urokinase
1. Before application of this product, patients should be determined for
hematocrit, platelet count, thrombin time (TT), prothrombin time (PT), and
activated partial thromboplastin time (APTT). TT and APTT should be less than
2-fold extension range;
2. During medication, patients' reactions should be closely observed, such
as pulse rate, body temperature, respiratory rate, blood pressure, bleeding
tendency, etc., and recorded at least once every 4 hours;
3. During intravenous administration, puncture is required to be successful
once to avoid local bleeding or hematoma;
4. During arterial puncture administration, pressure should be applied to
the puncture area for at least 30 minutes after administration, and then
pressurized and bandaged with sterile bandage and dressing to avoid
bleeding;
5.The use of this product in the following circumstances will increase the
risk, should weigh the advantages and disadvantages after careful use of this
product;
(1) Patients who delivered within the last 10 days, underwent tissue
biopsy, venipuncture or major surgery, and patients with severe gastrointestinal
bleeding;
(2) Patients at high risk of left ventricular thrombosis, such as mitral
stenosis with atrial fibrillation;
(3) Patients with subacute bacterial endocarditis;
(4) Patients with bleeding tendency or coagulation disorder secondary to
liver and kidney diseases;
(5) Pregnant women, cerebrovascular disease, and diabetic hemorrhagic
retinopathy.
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