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Pharmacological effects of urokinase
This product acts directly on the endogenous fibrinolysis system, can
catalyze the lysis of fibrinogen into fibrinolytic enzyme, the latter can not
only degrade fibrinogen clots, but also degrade the fibrinogen, coagulation
factor Ⅴ and coagulation factor in blood circulation, so as to play the role of
thrombolysis. This product has a quick and good effect on newly formed thrombus.
This product can also improve vascular ADP enzyme activity, inhibit ADP-induced
platelet aggregation, prevent thrombosis. After intravenous infusion of the
product, the activity of fibrinolytic enzyme in patients was significantly
increased. A few hours after drug withdrawal, plasminase activity returned to
its original level. However, the decrease in plasma fibrin or fibrinogen levels
and the increase in their degradation products can last for 12 to 24 hours.
Thrombolytic effect was significantly correlated with drug dose and time window
of administration.
The toxicity of this product is very low, and the 50% lethal dose of
intravenous injection in mice is more than 1 million IU/kg body weight. There is
no obvious antigenicity, teratogenicity, carcinogenicity and mutagenicity.
Anaphylaxis is rarely reported in clinical application. However, since this
product increases plasminogen activity and reduces unbound plasminogen and
fibrin-bound plasminogen in circulation, there may be a serious risk of
bleeding.
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