Gastrointestinal surgery can lead to the activation of a variety of
inflammatory mediators in the body, and release a large number of lysosomal
enzymes and oxygen free radicals after surgery, leading to the destruction of
gastrointestinal immune barrier, fibrinolytic system and coagulation system
disorders, and aggravating postoperative tissue damage. In addition,
gastrointestinal surgery can also lead to postoperative body immunity, abdominal
infection and other complications, which will affect the prognosis of patients.
Ulinastatin for injection can be used in the treatment of gastrointestinal
surgery, so, the effect of ulinastatin for injection on gastrointestinal
tract.
Ulinastatin for injection is a broad-spectrum protease inhibitor that can
recognize and bind to cell membrane receptors, and its 10th serine chondroitin
sulfate sugar chain has a negative charge, which can stabilize cell membrane and
lysosomal membrane, inhibit the activity of chymotrypsin and trypsin in disease
state, and contribute to stabilize membrane structure 50. In recent years,
studies have also shown that ulinastatin can improve tissue perfusion and
microcirculation, effectively eliminate oxygen free radicals, inhibit the
excessive release of inflammatory mediators, reduce the damage caused by
inflammatory damage and peroxidation, inhibit the coagulation factor, prevent
the conversion of prothrombin to thrombin, and improve the coagulation function
of patients.
The results showed that ulinastar J injection had a great effect on
postoperative inflammatory factors of gastrointestinal tract and peripheral
blood T lymphocyte subgroups, and could effectively promote the release of
inflammatory mediators in the body, improve cellular immune function, enhance
the body's resistance, and reduce stress and damage to functional organs caused
by surgery.
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