Basic components of organizational structure
DS is the main component of proteoglycan in the outer layer of vascular
(1) participate in cell signal transduction
(2) regulate cell adhesion
(3) maintenance and inhibition of cell growth: participate in nucleic acid
metabolism, increase the biosynthetic of messenger RNA (mRNA) and
deoxyribonucleic acid (DNA) of cells, and promote cell metabolism.
Participate in the pathophysiological process
(1) cardiovascular disease
Antithrombotic effect. (1) the anticoagulant effect is moderate, the
activity is low, and there is no inhibitory effect on Xa, which is 1/40 of the
effect of heparin. It inhibits and inactivates thrombin in plasma, instead of
inhibiting the activation of prothrombin; (2) by heparin cofactors Ⅰ
antithrombotic (HC - Ⅰ) route, and LMWH (low molecular heparin) or routine liver
has been called the synergy, combined application of anticoagulant effect of
reinforcement; (3) inhibition of collagen-induced platelet aggregation (Pt); (4)
lower limb perfusion in rats showed that DS promoted the release of tissue-type
plasminogen activator (tPA) by endothelial cells.
Protect the vessel wall and decrease the permeability of plasma
DS can remove lipids and lipoproteins from the blood in the body, remove
cholesterol from blood vessels around the heart, prevent atherosclerosis, and
increase the conversion rate of lipids and fatty acids in cells.
(5) wound repair and fibrosis