Human chorionic gonadotropin manufacturers
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Human chorionic gonadotropin (hCG) is a glycoprotein secreted by
trophoblast cells of placenta. It is composed of α - and β - dimer
glycoproteins. The α subunit of glycoprotein hormone with molecular weight of
36700 is similar to that of FSH (follicle stimulating hormone), LH (luteinizing
hormone) and TSH (thyroid stimulating hormone) secreted by pituitary gland, so
they can cross react with each other, but the structure of β subunit is not
In mature women, the fertilized eggs move into the uterine cavity and
are implanted into the uterus. During the development of the fetus, the
syncytiotrophoblast cells of the placenta produce a large amount of hCG, which
can be excreted into the urine through the blood circulation of pregnant women.
The hCG levels in serum and urine increased rapidly from 1 to 2.5 weeks of
gestation, peaked at the 8th week of pregnancy, and then decreased to the medium
level at the 4th month of pregnancy, and maintained until the end of pregnancy.
At present, the commonly used detection methods are: latex set inhibition test
and hemagglutination inhibition test; radioimmunoassay (RIA); enzyme linked
immunosorbent assay (ELISA); monoclonal antibody colloidal gold test.
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