In ulinastatin, there are two Kunitz domains with hydrolase inhibitory
activity, and the two sugar chains connected with the peptide chain are the
sulfated chondroitin sugar chain and an N-linked oligosaccharide, and the gray
indicates the sulfated sugar.
Ulinastatin, also known as urinary trypsin inhibitor, is a kind of
glycoprotein from human body, which is involved in the regulation of
inflammatory response in blood. It is a kind of innate immune-related substance,
which can inhibit the excessive activation of white blood cells, protect the
vascular endothelium and basement membrane, and inhibit the increase of vascular
permeability. It is clinically used as a therapeutic drug for acute inflammatory
response.
The total content of ulinastatin in the blood is very rich, which mainly
exists in the former body form. The inactive precursor has a high molecular
weight and weak affinity with proteolytic enzymes. It is not easy to be filtered
out into the urine by the kidney, which is the way for the body to store
ulinastatin. Free ulinastatin has inhibitory activity on proteolytic enzymes
released in various inflammatory reactions, accounting for 2% ~ 10% of the total
content.
That's all about ulinastatin. Stay tuned for more.