Ulinastatin background and overview
Ulinastatin is a glycoprotein with protease inhibitor effect, which was
first isolated from human urine. Ulinastatin had a strong inhibitory effect on
trypsin and had significant effects on -chymotrypsin, hyaluronidase and plasmin.
At the same time, ulinastatin also has good efficacy in severe inflammatory
reactions such as sepsis and severe pancreatitis, and is considered as a
beneficial immunomodulator. The anti-inflammatory effect of ulinastatin is
related to its inhibition of inflammatory response and lymphocyte apoptosis, and
its protective effect on tissues, organs and endothelial cells may also be
involved in the anti-inflammatory response of ulinastatin.
The pharmacological action of ulinastatin
This strain is a refined glycoprotein extracted from human urine and
belongs to protease inhibitor. It can inhibit the activity of trypsin and other
trypsin, and is often used in the treatment of pancreatitis. In addition, the
product has the functions of stabilizing lysosomal membrane, inhibiting the
release of lysosomal enzyme and inhibiting the production of myocardial
inhibitory factors, so it can be used in the rescue treatment of acute
The pharmacokinetics of ulinastatin
After intravenous administration of 300 thousand units /10ml in healthy
normal men, the blood drug concentration plummets within 3 hours and the
clearance half-life is 40 minutes. 24% of the dose administered was excreted in
the urine six hours after administration.
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