1. Pharmacological action of ulinastatin
Ulinastatin is a refined glycoprotein extracted from human urine, which can
inhibit trypsin and other trypsin, stabilize lysosomal membrane, inhibit the
release of lysosomal enzyme, inhibit the production of myocardial MDF, and
improve the circulation state in shock. Clinical and aprotinin double blind test
confirmed that ulinastatin had obvious effect on various kinds of shock.
2. Pharmacokinetics of ulinastatin
After ulinastatin injection, the plasma concentration decreased rapidly,
mainly in the kidney, liver and pancreas. It was eliminated from almost all
tissues, with a biological half-life of about 24min and a half-life of about
40min. After 6h of administration, low molecular metabolites were excreted in
urine, and excreted 24%. No accumulation was observed after continuous
administration for 7 days.
3. Indications of ulinastatin
Acute pancreatitis (including acute pancreatitis after traumatic,
postoperative and endoscopic retrograde cholangiopancreatography), acute
worsening of chronic recurrent pancreatitis, acute circulatory failure
(hemorrhagic shock, bacterial shock, traumatic shock, burn shock); It is also
widely used in thoracic surgery, digestive surgery, tumor surgery, organ
transplantation, organ resection and CPB surgery. This product is also used to
treat and prevent renal dysfunction caused by tumor chemotherapy.
Above is the content of ulinastatin, if you want to know more, please
continue to pay attention to Kangyuan company, we will be at your service.