Urokinase should be prepared with sterilized saline or 5% glucose solution
for injection before use.
1. Pulmonary embolism: the initial dose of 4,400 units/kg of body weight
was prepared with normal saline solution or 5% glucose solution, and was
finished in 10 minutes at the speed of 90ml/h; Subsequently, intravenous
infusion was administered at a rate of 4,400 units per hour for 2 or 12 hours.
In the case of pulmonary embolism, it can also be injected through the pulmonary
artery after being prepared with normal saline at 15,000 units per kilogram of
body weight. If necessary, the dosage can be adjusted according to the disease,
and the drug can be repeated once every 24 hours, with a maximum of three
times.
2. Myocardial infarction: It is suggested that after the preparation with
normal saline, the coronary artery should be continuously administered for 2
hours at the rate of 6000 units/min. Before the infusion, heparin 2500 ~ 10000
units should be given intravenously. The product can also be prepared in 2 to 3
million units after intravenous drip, 45 minutes to 90 minutes.
3. Peripheral arterial thrombosis: The product was prepared with normal
saline (concentration: 2500 units/ml) and blood clot was injected through a
catheter at a speed of 4000 units/min, and the catheter was cliped once every 2
hours; The infusion rate can be adjusted to 1000 units/min until the clot
dissolves.
4. Prevention and treatment of thrombosis after heart valve replacement:
Thrombosis is one of the most common complications after heart valve
replacement. This product can be used 4400 units/kg body weight, 10 minutes to
15 minutes after the preparation of normal saline drops. They were then
maintained by iv drip at 4400 units/kg bW/h. When the valve function is normal,
the drug is discontinued. Discontinue medication if medication is not effective
within 24 hours or if there is a tendency to severe bleeding.
5. Empyema or pericardial abscess: when commonly treated with antibiotics
and drainage of pus, the drainage tube is often blocked by fibrin clots. At this
point, 10,000 to 250,000 units of the product (5000 units/ml) can be prepared by
injecting sterilizing water into the pleural cavity or pericardial cavity. It
can keep the drainage tube unobstructed and prevent pleural or pericardial
adhesion or pericardial constriction.
6. Ophthalmic application: used to dissolve the anterior chamber blood clot
caused by intraocular hemorrhage. It disintegrates the blood clot and
facilitates surgical removal. Often dosage is 5000 units with 2 milliliter
normal saline make up rinse front room.
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