Composition of human chorionic gonadotropin
Human chorionic gonadotropin is a glycoprotein secreted by trophoblastic
cells of the placenta. Human chorionic gonadotrophin (HCG) - - is synthesized
from syncytiotrophoblast cells. The glycoprotein hormones with molecular weight
of 36700 are basically similar to the FSH (follicle stimulating hormone), LH
(luteinizing hormone) and TSH (thyrotropin) secreted by the pituitary, so they
can cross react with each other, while the structure of each subunit is
different. Ak-hcg is similar in structure to ak-lh, but the last 24 amino acid
extensions are not present in ak-lh.
Human chorionic gonadotropin information
In mature women, the fertilized egg moves to the uterine cavity for
implantation and forms an embryo. In the process of developing into a fetus, the
syncytiotrophoblast cells of the placenta produce a large amount of human
chorionic gonadotropin (HCG), which can be excreted into the urine through the
blood circulation of the pregnant woman. Serum and urine HCG levels rise rapidly
between 1 and 2.5 weeks gestation, peak at 8 weeks of gestation, drop to
moderate levels by 4 months of gestation, and remain at the end of
gestation.