Changes of human chorionic gonadotropin
Human chorionic gonadotrophin enters the mother's blood after fertilization
and proliferates rapidly until the 8th week of pregnancy, then slowly decreases
in concentration until the 18th to 20th week, and then remains stable. In an
average intact human, chorionic gonadotropin levels rise to at least 2.5 MoM
before being associated with down syndrome. However, the average level of human
chorionic gonadotropin in the mother blood of DS patients was only 1.3MoM, which
could not clearly identify DS patients. The human chorionic gonadotropin-related
molecules used for DS examination had free b-hcg and high glucose hCG
The levels of human chorionic gonadotropin-related molecules are also
related to the sex of the fetus.
The complete human chorionic gonadotropin is produced entirely from the
syncytiotrophoblast of the placental chorionic membrane. Human chorionic
gonadotropin is produced by trophoblastic transitional cells and somatic cells.
Human chorionic gonadotropin is secreted from 10 to 14 days after