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Introduction of human gonadotropin at menopause

  Introduction of human gonadotropin at menopause

  1, the application

  The gonadotropin made from the pituitary gland of animals has been widely used in animal husbandry and aquaculture, but it is not effective for human beings. HCG can be made from the urine of pregnant women, or the mixed preparation of LH and FSH extracted from the urine of menopausal women, referred to as human menopausal gonadotropin (HMG), clinical can be used to treat sexual dysfunction.

Introduction of human gonadotropin at menopause

  2. Secretion mechanism

  The production and release of pituitary gonadotropin is directly regulated by luteinizing hormone releasing hormone (LH-RH) in the hypothalamus. Sex hormones, the target products of LH and FSH, in turn affect the secretion function of pituitary or hypothalamus. Therefore, the secretion of lh-rh, LH and FSH as well as the sex hormones are restricted by each other, and the fluctuations are quite rhythmic. The recurrence of the female menstrual cycle is the result of fluctuations and rhythmic changes in the secretion of these three hormones.

  3, structure,

  Gonadotropin (LH, FSH, HCG) and thyrotrophin (TSH) are composed of two peptide chains of peptide and peptide through non-covalent bond combination, and contain glycosyl group. The glycosyl group is partially covalently bound to individual asparagine residues, serine residues or threonine residues on the peptide chain. The two peptide chains can be separated and recombined. LH, FSH, HCG and TSH have the same structure of the peptide chain, while the peptide chain has its own characteristics, which determines the functional specificity of the above-mentioned hormones.