Industry Information

Physical and chemical properties and functions of ulinastatin

  Ulinastatin (UTI) is a broad-spectrum proteolytic enzyme inhibitor isolated and purified from male urine. Currently, it is widely used in the adjuvant treatment of acute severe pancreatitis, acute renal failure, severe infection, and extracorporeal circulation and organ transplantation [1]. In recent years, it has also been applied to patients with severe burns and achieved good results. The purpose of this article is to review the therapeutic effects of early use of ulinastatin in patients with severe burns.

Physical and chemical properties and functions of ulinastatin

  Ulinastatin (UTI) is an acidic sugar protein composed of 143 amino acids with a molecular weight of approximately 67000D. It consists of three functional domains: O connected glycosylation region, n-terminal Kunitz type domain I, and c-terminal Kunitz type domain II. The enzyme inhibitory activity of ulinastatin is mainly located in two Kunitz type domains, which have a wide spectrum of inhibitory enzymes and do not overlap completely. It can widely inhibit the activity of trypsin, trypsin, trypsin, lipase, hyaluronidase, elastase, cathepsin G and other hydrolytic enzymes. The main function of O junction glycosylated region is to stabilize the cell membrane and lysosome and prevent the release of lysosomal enzymes [3]. Studies have shown that ulinastatin also inhibits the excessive release of a variety of inflammatory mediators such as interleukin-il-1, il-6, and il-8, tumor necrosis factor-alpha (TNF- alpha), and myelperoxidase (MPD). Block the formation of endogenous shock factor, scavenge oxygen free radicals, regulate immune function, protect the function of internal organs.