Industry Information

Effects and side effects of urokinase

  One, the role of urokinase

  1. This product is mainly used for thrombolysis treatment of thromboembolic disorders, including: acute diffuse pulmonary embolism, chest pain, 6 ~ 12 hours and myocardial infarction, coronary artery embolism symptom of shorter than 3 ~ 6 hours of acute cerebral embolism, retinal artery embolism and other peripheral artery embolism severe symptoms of iliac and femoral venous thrombosis.

  2. This product is also used to prevent thrombosis after artificial heart valve surgery, and to keep the vascular intubation, thoracic cavity and pericardial cavity drainage tube unobtrusive. The efficacy of thrombolytic therapy requires the maintenance of subsequent heparin anticoagulation.

Effects and side effects of urokinase

  Second, urokinase side effects

  1, bleeding: can be superficial bleeding (mainly in the skin, mucosa and vascular puncture sites), can also be visceral bleeding (digestive tract bleeding, hemoptysis, urine blood, retroperitoneal bleeding, cerebral hemorrhage, etc.), serious need for blood transfusion, or even lead to death. The incidence of severe hemorrhage is about 1% ~ 5%, and the incidence of cerebral hemorrhage is generally < 1%. In case of serious bleeding complications, infusion should be stopped immediately. If necessary, fresh blood or red blood cells, fibrinogen, etc., can also be injected with anti-fibrinolytic drugs such as aminohexanoic acid to stop bleeding, but the effect is usually not significant. The prevention of bleeding mainly consists of strict selection of indications and contraindications, establishment of venous access in advance, and prohibition of intramuscular injection after infusion.

  2. This product is an endogenous plasminogen activator without antigenicity, but some patients may have mild allergic reactions, such as rash, bronchospasm and fever.

  3. Gastrointestinal reactions: nausea, vomiting and loss of appetite.

  4. SGPT may be elevated.