Industry Information

The purpose of urokinase

  Urokinase is a traditional thrombolytic drug which has been operated in China for many years. It is widely used in a variety of vascular embolism diseases such as acute myocardial infarction, cerebral thrombosis, pulmonary vein thrombosis, and lower limb vein thrombosis. This project used molecular design and gene site-directed mutation technology to obtain urokinase provariant gene (patented), and to prepare urokinase variant (Super UK) through escherichia coli genetic engineering. Urokinase was obtained by this method without fibrinolytic enzyme activation, and directly changed into urokinase under the action of its intrinsic enzyme activity, without any human raw materials, and without any potential risk of virus contamination.

The purpose of urokinase

  Urokinase is mainly used for thrombolytic treatment of thromboembolic diseases. These included acute generalized pulmonary embolism, coronary artery embolization and myocardial infarction within 6-12 hours of chest pain, acute stage cerebral embolization with symptoms shorter than 3-6 hours, retinal artery embolization, and other severe peripheral arterial embolization of ilio-femoral vein thrombosis. It is also used to prevent thrombus formation after artificial heart flap operation, and to keep the vascular intubation and the thoracic cavity and pericardial cavity drainage tube unobtrusive.