Human chorionic gonadotropin is a glycoprotein hormone secreted by the
placenta. The fluid of healthy non-pregnant women contains no or very little
human chorionic gonadotropin (typically no more than 10U/L). After pregnancy,
the content of human chorionic gonadotrophin increases continuously, which is
about 25U/L at 7-8d of pregnancy, and about 50U/L at 10d of pregnancy, and
reaches up to 200 000U/ L at 2 months of pregnancy, and then decreases
gradually. In recent years, the commonly used methods for the determination of
human chorionic gonadotropin in urine include latex agglutination, double
antibody sandwich enzyme immunoassay and immunogold sol speckle filtration
assay.
Serum: male and female (non-pregnant) less than 5U/L; Pregnant women: 5 ~
50U/L within 1 week, 50 ~ 500U/L at 2 weeks, 100 ~ 10000u /L at 3 weeks, 3,500 ~
115000u /L at 4 weeks, 12,000 ~ 270u /L at 6 ~ 8 weeks, 15,000 ~ 220oo0u /L at
12 weeks. Urine: 13 000 ~ 105 000 u /L during pregnancy.
[clinical significance] the detection of human chorionic gonadotropin is
mainly used for the diagnosis of pregnancy and chorionic carcinoma and other
malignant tumors. Increased: in the normal pregnancy, early pregnancy,
choriocarcinoma, hydatidiform mole, ectopic pregnancy, cervical cancer, ovarian
cancer, testicular tumor, stomach cancer, liver cancer, pancreatic cancer,
breast cancer, pregnancy toxicemia. Reduced: seen in threatened abortion,
etc.