Industry Information

Reference value and clinical significance of human chorionic gonadotropin

  Human chorionic gonadotropin is a glycoprotein hormone secreted by the placenta. The fluid of healthy non-pregnant women contains no or very little human chorionic gonadotropin (typically no more than 10U/L). After pregnancy, the content of human chorionic gonadotrophin increases continuously, which is about 25U/L at 7-8d of pregnancy, and about 50U/L at 10d of pregnancy, and reaches up to 200 000U/ L at 2 months of pregnancy, and then decreases gradually. In recent years, the commonly used methods for the determination of human chorionic gonadotropin in urine include latex agglutination, double antibody sandwich enzyme immunoassay and immunogold sol speckle filtration assay.

  Serum: male and female (non-pregnant) less than 5U/L; Pregnant women: 5 ~ 50U/L within 1 week, 50 ~ 500U/L at 2 weeks, 100 ~ 10000u /L at 3 weeks, 3,500 ~ 115000u /L at 4 weeks, 12,000 ~ 270u /L at 6 ~ 8 weeks, 15,000 ~ 220oo0u /L at 12 weeks. Urine: 13 000 ~ 105 000 u /L during pregnancy.

  [clinical significance] the detection of human chorionic gonadotropin is mainly used for the diagnosis of pregnancy and chorionic carcinoma and other malignant tumors. Increased: in the normal pregnancy, early pregnancy, choriocarcinoma, hydatidiform mole, ectopic pregnancy, cervical cancer, ovarian cancer, testicular tumor, stomach cancer, liver cancer, pancreatic cancer, breast cancer, pregnancy toxicemia. Reduced: seen in threatened abortion, etc.