The anti-inflammatory effect of ulinastatin
When the local inflammation, capillaries within the "chemokine" (ICAM - Ⅰ)
in inflammatory peripheral region; This causes the accumulation of neutrophils
in the blood. When neutrophils aggregate, they release "granulocyte elastase,"
an enzyme that destroys normal cells, activating and releasing inflammatory
factors inside the cells. At the same time, granulocyte elastase also hydrolyzes
the precursor of ulinastatin (IaI) into ulinastatin, which in turn binds to the
hydrolytic enzyme, rendering it inactive.