Industry Information

Urokinase second generation thrombolytic drug

  Second generation thrombolytic drugs

  Represented by recombinant human tissue-type plasminogen activator (rt-pa, alteplase),

  Such drugs with anticoagulant drug combination, thrombolysis ability is the first generation of thrombolytic drugs to further improve, and the fibrous protein specificity is high, low and systemic fibrinolytic response, can avoid to cause the original circular fibrinogen and fibrinolytic enzyme exhausted state of systemic thrombolysis, reduce the occurrence of systemic risk of bleeding, but the drugs needed for the treatment of myocardial infarction, dosage is bigger, also can cause circulation fibrin and fibrinolytic enzyme was mild or moderate decrease, and drug delivery way too complicated.

Urokinase second generation thrombolytic drug

  Urokinase original

  A single - stranded polypeptide consisting of 411 amino acid residues.

  Mechanism of action:

  Recognition of thrombus: activated by fibrinolytic enzyme and kalin-releasing enzyme on the surface of thrombus, part of which becomes double-stranded UK. The latter activates fibrinolytic enzyme bound on the surface of thrombus to become fibrinolytic enzyme, which partially dissolves thrombofibrin.


  From the Y/E fragment, fibrinolytic enzyme generated by urokinase activation converts the urokinase in the vicinity of the blood clot into UK, which is a non-specific activator, which can massively activate all the bound fibrinolytic enzymes on the blood clot (regardless of the D domain or Y/E fragment) and the surrounding free fibrinolytic enzymes, thus leading to the rapid degradation of the blood clot. By the action of proteolytic enzyme inhibitors in the blood, the effect of UK and plasmin is limited to the vicinity of blood clots, so that urokinase-induced thrombolysis is thrombo-specific.

  Urokinase is the precursor of urokinase, which is inactive after entering the blood. After recognizing the Y/E segment on the surface of thrombus, it is activated by the action of kinin, which is converted into urokinase, and then plays the role of thrombolysis.

  Prourokinase has long