Thrombolysis is an important milestone in the treatment of acute myocardial
infarction, and the original tissue fibrinolytic enzyme activators are by far
the most effective thrombolytic drugs, especially the listed at o enzyme,
represents a specific era of thrombolytic drugs, but based on the situation of
our country, the first generation of nonspecific drug urokinase is still the
most popular of thrombolytic drugs.
The first generation of thrombolytic drugs
Represented by streptokinase (SK) and urokinase (UK),
This class of thrombolytic drugs can be effective thrombolytic, but not
fibrin-specific, and streptokinase has immunogenicity, easy to cause drug
resistance, fever and allergy
urokinase
Discovered by Wiuiams in 1951
Urine by humans or human kidney culture of a kind of serine protease, is
composed of two polypeptide chain, originally the fibrin nonselective, can be
directly activate fibrinolytic enzyme, make it into a fibrinolytic enzyme that
fibrin clot, fibrinogen and blood coagulation factor V before and VIII
degradation, and decompose fibrin deposits related to the blood clot and the
role of, can seep into the fresh blood clots within are attached to the fibrous
protein fiber online are more likely to activate enzymes, prompting fresh
thrombus dissolving, the old have been getting our machine thrombus is
invalid.
Half-life 16 minutes
Note: bleeding may occur at higher doses
Therefore, the second generation of thrombolytic drugs focusing on specific
plasminogen came into being.